Semax is a synthetic peptide developed in Russia with nootropic (cognitive-enhancing) and neuroprotective properties. It is derived from a fragment of the naturally occurring peptide ACTH (adrenocorticotropic hormone), but it is modified to have fewer side effects while maintaining its beneficial effects on the brain. Semax is primarily used to enhance memory, focus, and learning ability, as well as to reduce anxiety and promote neuroprotection.
It is believed to work by stimulating the release of brain-derived neurotrophic factor (BDNF), which supports neuronal health and plasticity, and by influencing the balance of neurotransmitters such as dopamine and serotonin. Semax is also thought to help reduce the impact of stress and improve overall brain function.
Semax is commonly administered as an intranasal spray or nasal drops and is used in various cognitive and mood-related conditions, including cognitive decline, anxiety, and depression. It is popular in Russia and other countries as a cognitive enhancer and neuroprotective agent but is still undergoing research for its broader clinical use.